The gene delivery system for rheumatoid synovium

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The gene delivery system for rheumatoid synovium.

A gene therapy of synovial tissue is potentially a novel therapeutic method in rheumatoid arthritis (RA). The method induces expression of anti-arthritic molecules in target cells, and is also useful for the investigation of novel therapeutic targets in vitro. Previous studies showed that viral vectors, which can infect non-proliferative cells well, i.e. adenovirus-based vector, were effective ...

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Objective(s): PEI based nanoparticle (NP) due to dual capabilities of proton sponge and DNA binding is known as powerful tool for nucleic acid delivery to cells. However, serious cytotoxicity and complicated conditions, which govern NPs properties and its interactions with cells practically, hindered achievement to high transfection efficiency. Here, we have tried to optimize the properties of ...

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The Synovium in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease targeting multiple joints. The synovium is the primary site of the inflammatory process, which if untreated leads to irreversible damage to the adjacent cartilage and bone. It is now well established that autoantibodies that are characteristic of RA, including rheumatoid factor (RF) and anti-citrulluninated protein antibodies (ACPA), are...

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Efficient Non-viral Gene Delivery in Vivo into Synovium

INTRODUCTION:• Gene delivery into joints is considered to become a useful strategy for the treatment of joint diseases. Viral vectors are commonly used because of their high transduction efficacies. Despite of recent improvement of the vectors, the viral vectors are associated with some unsolved problems such as induction of inflammatory responses and undesired generation of replication-compete...

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Local Gene Delivery System by Bubble Liposomes and Ultrasound Exposure into Joint Synovium

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ژورنال

عنوان ژورنال: Japanese Journal of Clinical Immunology

سال: 2008

ISSN: 0911-4300,1349-7413

DOI: 10.2177/jsci.31.17